HIGHLIGHTS
- who: ADAM et al. from the University of of Denmark, Copenhagen, Denmark have published the Article: macrophage-promoted cancer cell invasion Biotech Research and Innovation, in the Journal: (JOURNAL)
- what: The authors provide evidence that mediates a paracrine EGFR-ligand-chemokine feedback loop whereby cancer cells hijack macrophages to promote tumor progression. The authors report that the expression of ADAM17 correlates to the expression of protumorigenic macrophage markers in human cohorts and regulates the phenotype of macrophages in mouse tumors. The authors show that ADAM17 sheds heparin-binding EGF (HB-EGF) and amphiregulin (AREG) from . . .
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