HIGHLIGHTS
- who: Tatiana Cardinal and colleagues from the hospitalier universitaire Sainte-Justine, Canada have published the Article: Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression, in the Journal: (JOURNAL)
- what: Through sex-stratified transcriptome analyses and targeted overexpression in ENS progenitors the authors show that male-biased ENS malformation in TashT embryos is not due to upregulation of Sry-the murine ortholog of candidate gene for the HSCR male bias in humans-but instead involves upregulation of another Y-linked gene Ddx3y . . .
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