Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming

HIGHLIGHTS

  • who: Yuanzheng Liang from the Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China have published the research: Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming, in the Journal: (JOURNAL)
  • what: The structural variations catalog (Supplementary Fig 2A) in this study showed significant genomic instability in the majority of chromosomes, except for chr4, including deletion (DEL), duplication, inversion, and insertion (INS). Multiu2011omics abnormal program identification of primitive MM malignant progenitor cells Subsequently, the authors focused on primitive MM cell subpopulations, including type I and IX malignant progenitor cells, which . . .

     

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