Manual and automatic assignment of two different aβ40 amyloid fibril polymorphs using mas solid-state nmr spectroscopy

HIGHLIGHTS

  • What: The authors present an analysis of the secondary chemical shifts and a discussion on the differences between the manual and automated assignment strategies. The authors focus on assigning and characterizing two very similar yet different polymorphs of amyloid fibrils formed by Alzheimer`s disease β-amyloid peptide 1-40 (Aβ40).
  • Who: Natalia Rodina et al. from the Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Munich, Germany have published the research work: Biomolecular NMR Assignments (2024) 18:201-212 Manual and automatic assignment of two different Aβ40 amyloid fibril . . .

     

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