Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating cd4+⠋t cell proliferation

HIGHLIGHTS

• who: Dingxi Zhou from the (UNIVERSITY) have published the paper: Mapping autophagosome contents identifies interleukin-7 receptor-u03b1 as a key cargo modulating CD4+u280bT cell proliferation, in the Journal: (JOURNAL)
• what: This study shows that key autophagy substrates can be reliably identified in this mouse model and help mechanistically unravel autophagy`s contribution to healthy physiology and disease. Next, the authors aimed to identify the proteins that are selectively degraded by autophagy by using proximity labelling. Using a powerful mouse model based on the proximity biotinylation technique, the authors demonstrate that autophagic degradation of . . .
  

   

  

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