Mapping sp-c co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation

HIGHLIGHTS

• who: Kristine F. R. Pobre-Piza from the Research Hospital have published the Article: Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors sought to determine if the TANGO algorithm could be used to predict binding_sites for these BiP co-chaperones in the context of a full-length protein. The authors show that the TANGO algorithm identifies three sites in the SP-C sequence with varying aggregation propensity. While determining if the various TANGO-predicted sequences were . . .
  

   

  

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