Mapping the functional interaction of sco1 and cox2 in cytochrome oxidase biogenesis*

HIGHLIGHTS

• who: Kevin Rigby from the Kevin Rigby, Paul ACobine, Oleh Khalimonchuk, and Dennis R. Winge, From the Departments of Medicine and Biochemistry, University of Utah Health Sciences Center, Salt Lake City, Utah , Sco, is implicated in the copper metallation of the CuA site in Cox, of cytochrome oxidase. The structure of Sco, in the metallated and apo-conformers revealed structural dynamics primarily in an exposed region designated loop, . The structural dynamics of loop , in Sco, suggests it may be an interface for interactions with Cox17, the Cu(I) donor and/or Cox2. A series of conserved residues . . .
  

   

  

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