HIGHLIGHTS
- who: Joel E. Beevers from the University of Oxford, South Parks Road, Oxford , QX, UK have published the research work: MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons, in the Journal: (JOURNAL)
- what: The studies have shown that the H2 haplotype expresses twice as much exon 2+3+ MAPT transcript as H1 (Caffrey et_al, 2008), a finding that has been replicated in a large postmortem brain series (Trabzuni et_al, 2012). The authors demonstrate that the dopaminergic neuronal cultures express 22% greater tau transcripts from the H1 . . .
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