Masp-2 is a heparin-binding protease; identification of blocking oligosaccharides

HIGHLIGHTS

  • who: Jacob van den Born from the Department of Nephrology, University Medical Center Groningen, Groningen, Netherlands, UnivGrenoble Alpes, CNRS, Georgia, Athens, GA, United States, Ronzoni Institute, Milan, Italy have published the paper: MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides, in the Journal: (JOURNAL)
  • what: The authors aimed at identifying pathway-specific complement inhibiting GAGs from a library of natural and enzymatically and chemically modified and/or depolymerized GAGs. The authors show that small heparin- and HS-derived oligosaccharides are specific inhibitors of the LP of complement and that these sugars inhibit . . .

     

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