Mass spectrometric analysis of the hiv-1 integrase-pyridoxal 5⠲-phosphate complex reveals a new binding site for a nucleotide inhibitor*

HIGHLIGHTS

• who: Kerry L. Williams from the (UNIVERSITY) have published the research work: Mass Spectrometric Analysis of the HIV-1 Integrase-Pyridoxal 5⠲-Phosphate Complex Reveals a New Binding Site for a Nucleotide Inhibitor*, in the Journal: (JOURNAL) of December/22,/2004
• what: The interest in this compound was prompted for the following reasons. The authors show a correlation between PLP modification of Lys244 and inhibition of IN catalytic activities as well as formation of the IN䡠DNA complex. The structural information the authors report here facilitates a more rational approach toward improving selectivity and potency . . .
  

   

  

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