Mass spectrometry imaging and lc/ms reveal decreased cerebellar phosphoinositides in niemann-pick type c1-null mice[s]

HIGHLIGHTS

• who: Koralege C. Pathmasiri from the DepartmentUniversity of have published the Article: Mass spectrometry imaging and LC/MS reveal decreased cerebellar phosphoinositides in Niemann-Pick type C1-null mice[S], in the Journal: (JOURNAL)
• what: The authors show that PIP2 and PIP are decreased in cerebellar tissue from the NPC1 mouse model as early as 3 weeks of age, whereas a decrease in PI is observed at a later stage of the disease progression by LC/MS. MSI reveals overall decreased levels of PIP2 and PI, consistent with LC/MS data; however, no specific regional . . .
  

   

  

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