Massive accumulation of sphingomyelin affects the lysosomal and mitochondria compartments and promotes apoptosis in niemann-pick disease type a

HIGHLIGHTS

• who: Emma Veronica Carsana from the Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy have published the article: Massive Accumulation of Sphingomyelin Affects the Lysosomal and Mitochondria Compartments and Promotes Apoptosis in Niemann-Pick Disease Type A, in the Journal: (JOURNAL)
• what: The work provides a new in vitro model to study NPA etiopathology and suggests the existence of a pathogenic axis that with an impairment in the mitochondrial activity is responsible for the cell death. The authors used fibroblasts derived from a healthy subject and those derived from an NPA . . .
  

   

  

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