Mathematical modelling of cell migration: stiffness dependent jump rates result in durotaxis

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  • who: Adam A. Malik from the Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden have published the paper: Mathematical modelling of cell migration: stiffness dependent jump rates result in durotaxis, in the Journal: (JOURNAL)
  • what: The authors develop a stochastic model where the cell moves by updating the position of its adhesion sites at random times and the rate of updates is determined by the local stiffness of the substrate. The authors investigate two physiologically motivated mechanisms of stiffness sensing. The model shows quantitative agreement with experimental results in which cells tend to cluster . . .

     

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