HIGHLIGHTS
SUMMARY
The increase of several MMPs` expression and enzymatic activity, such as MMP-1, MMP-2, MMP-3, MMP-7, MMP9, MMP-10, and MMP-14, correlates with the aggressiveness of different types of cancer, which leads to consider them as prognostic markers and targets of new therapeutic strategies. For instance, a rise in serum MMP-2 levels has been identified in advanced stages of nonsmall cell lung cancer (NSCLC) compared with nonmetastatic lung cancer and control subjects. A significant correlation between cortisol and MMP-12 was not observed in LAC patients, but increased cortisol . . .
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