Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts

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  • who: Taryn Loomis from the University of have published the Article: Matrix stiffness and architecture drive fibro-adipogenic progenitorsu2019 activation into myofibroblasts, in the Journal: Scientific Reports Scientific Reports
  • what: The aim of this study was to investigate FAPs` sensitivity to their underlying substrate mechanics and architecture. The authors focused on proliferation and myofibroblast activation as measures of a | 12:13582 | 5 Vol.:(0123456789) | Vol:.(1234567890) 12:13582 | fibrotic phenotype and YAP localization as a potential mechanosensing pathway. This study provides novel insights into the mechanosensitivity of FAPs, which has not to the knowledge been . . .

     

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