Mct4/lactate promotes pd-l1 glycosylation in triple-negative breast cancer cells

HIGHLIGHTS

• who: Xianxian Duan and collaborators from the School of Medicine, Nankai University, Tianjin, China have published the paper: MCT4/Lactate Promotes PD-L1 Glycosylation in Triple-Negative Breast Cancer Cells, in the Journal: Journal of Oncology 4T1-luciferase of 26/09/2022
• what: We found that PD-L1 had a high sensitivity to MCT4 expression and lactate concentrations in TNBC, and lactate mainly promoted the N-glycosylation of PD-L1 by activating WNT pathway to incur its stable accumulation and expression on the cell membrane.
• how: Impressively WB results showed that PD-L1 . . .
  

   

  

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