Mda5 signaling induces type 1 ifn- and il-1-dependent lung vascular permeability which protects mice from opportunistic fungal infection

HIGHLIGHTS

• who: Michael J. Davis and collaborators from the Autonomous University of Nuevo León, Mexico have published the research: MDA5 signaling induces type 1 IFN- and IL-1-dependent lung vascular permeability which protects mice from opportunistic fungal infection, in the Journal: (JOURNAL)
• what: The authors demonstrate that pICLC signaling through MDA5 induces both t1IFN and inflammatory factors including IL-1 and IL-6 and all these pathways are critical for the downstream induction of lung vascular permeability. Although the authors acknowledge that these IL-10 protein induction data are less robust than those published . . .
  

   

  

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