HIGHLIGHTS
- who: Chen Liang and colleagues from the Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China have published the article: Mechanical Regulation of Redox Balance via the Induction of the PIN1/NRF2/ARE Axis in Pancreatic Cancer, in the Journal: (JOURNAL)
- what: The authors show that PIN1 expression is positively correlated with tumor stiffness and the stromal proportion in PDAC. Given the oncogenic effect of PIN1 on pancreatic tumorigenesis, the authors demonstrate that mechanical stress can upregulate PIN1 expression to decrease the reactive oxygen species (ROS) level and defend against oxidative stress.
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