Mechanical stress protects against chondrocyte pyroptosis through lipoxin a4 via synovial macrophage m2 subtype polarization in an osteoarthritis model

HIGHLIGHTS

• who: Posted Date March et al. from the Shengjing Hospital of China Medical University have published the research: Mechanical Stress Protects Against Chondrocyte Pyroptosis through Lipoxin A4 via Synovial Macrophage M2 Subtype Polarization in an Osteoarthritis Model, in the Journal: (JOURNAL)
• what: The authors show that cyclic tensile stress (CTS), similar to that experienced in the joint, initiates an inflammatory response via synovial macrophage polarization. The authors evaluated the effects of LXA4 on chondrocyte pyroptosis via synovial macrophage M2 subtype polarization and identified the mechanisms by which it supports exercise therapy for OA. The study . . .
  

   

  

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