HIGHLIGHTS
- who: Pascale Milani et al. from the Moléculaire et Cellulaire, CNRS/INSERM/Université Strasbourg, Illkirch, France have published the paper: Mechanics of the IL2RA Gene Activation Revealed by Modeling and Atomic Force Microscopy, in the Journal: (JOURNAL) of April/13,/2011
- what: Combining atomic force microscopy and computer modeling the authors investigate the structural and dynamical properties of the IL2RA promoter and identify an intrinsically negative supercoil in the PRRII region (containing Elf-1 and HMGA1 binding sites) located upstream of a curved DNA region encompassing TSS. The authors propose the following scenario for . . .
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