Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy

HIGHLIGHTS

• who: Francesca Margara from the DepartmentUniversity of have published the article: Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy, in the Journal: Scientific Reports Scientific Reports
• what: The model shows a stronger hypercontractility phenotype in MYH7R403Q/+, while TNNT2R92Q/+ ventricles exhibit a more severe diastolic dysfunction. Altogether, the organ simulations underline the efficacy of Mavacamten for genetic variants that alter myosin conformations, such as MYH7R403Q/+, but further suggest an unmet need in correction of cell to organ abnormalities caused by thin filament HCM, which the authors investigate below.
• how: The authors conducted human . . .
  

   

  

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