Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells*

HIGHLIGHTS

• who: Kiran Kumar Naidu Guturi from the results, we have established that ␤-catenin when phosphorylated at Ser, is a key factor in promoting EGFR expression and EGFR-dependent proliferation and survivalAll of these results strongly suggest that activation of ␤-catenin signaling may be associated with the progression of the disease through signaling cross-talk. Thus, our study can open a new in the combinatorial therapeutic approach which is currently under development in cancer treatment (42, , ). Acknowledgments-We thank Dr. K. M. Yamada (Chief, Laboratory of Cell and Developmental Biology, National Institute of Health/ NIDCR) and Dr. B . . .
  

   

  

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