HIGHLIGHTS
- who: Masahiro Nishida from the Oita University, Yufu, Oita, Japan have published the article: Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition, in the Journal: (JOURNAL) of 24/03/2022
- what: The authors discuss how Genz acts to CPT-resistant TOP1 carrying N722A or N722S mutation. The authors initially explored the mechanism of Genz-induced DSB formation.
- how: The result indicated that Genz was intercalated in the DNA strand and was directly held by the arginine at position 364 and aspartate at position 533 of TOP1 (Fig 6a . . .
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