HIGHLIGHTS
- who: Mridula Nambiar from the (UNIVERSITY) have published the paper: Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation*, in the Journal: (JOURNAL) of March/16,/2012
- what: For the first time, the authors show that RAGs can nick mcr; however, the mechanism is unique. The authors demonstrate that RAG binding and nicking at the mcr are independent of nonamer, whereas a CCACCTCT motif plays a critical role in its fragility, as shown by sequential mutagenesis. The authors propose CCACCTCT as the motif responsible for RAG cleavage at . . .
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