HIGHLIGHTS
- who: Deqiang Yuan from the The University of Texas Health Science Center at San Antonio, United States have published the research work: Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis, in the Journal: (JOURNAL)
- how: Cell and animal model results found that Hcy upregulates ER oxidoreductin-1u03b1 (Ero-1u03b1) expression by promoting binding of hypoxia-inducible factor-1u03b1 (HIF-1u03b1) to the Ero-1u03b1 promoter and downregulates the antioxidant pathway mediated by ER glutathione peroxidase (GPX) 7 to induce ERS and disrupt ER homeostasis .
- future: This review mainly summarizes the . . .
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