Mechanism of mirnas and mirna-mrna regulatory networks in modulating drug resistance in her2-positive breast cancer: an integrative bioinformatics approach

HIGHLIGHTS

• What: The data selection process of the study is illustrated by a PRISMA in Supplementary Figure S1.daFor mRNAs, differential expression analysisdiagram was conducted on three validation tasets. In the analysis of multiple the authors identified keyand molecular alterations associated were identified, comprising 240 datasets, upregulated (red points) 325 downregulated genes with HER2-targeted drug resistance in breast cancer. CXCR4 has been identified as a key regulator of metastasis in HER2 breast cancer, Interestingly, the analysis has revealed an association between higher CXCR4 expression with studies indicating that its inhibition can have a favorable impact on prognosis . . .
  

   

  

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