HIGHLIGHTS
- who: Tyler M. Weaver from the University of have published the paper: Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The work has provided novel mechanistic insight into how Rev1 utilizes the R324 protein template to prevent optimal hydrogen_bonding with incoming dTTP, dGTP, and dATP, thus accounting for the enzyme`s substrate specificity.
- future: It is interesting to speculate whether TLS polymerases may contribute to the accumulation of ribonucleotides in the genome though additional work is needed to understand the complex interplay between . . .
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