Mechanisms causing acantholysis in pemphigus-lessons from human skin

HIGHLIGHTS

  • who: Desalegn Tadesse Egu from the Munich, Germany University of Lu00fcbeck, Germany have published the article: Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin, in the Journal: (JOURNAL)
  • what: By this approach, mechanisms occurring in cell culture and mouse skin, but not in human epidermis, such as apoptotic cell death, also can be evaluated .

SUMMARY

    Although organ culture models are not best suited for biochemical studies, they provide a physiologically relevant setup to investigate mechanisms causing altered expression of desmosomal proteins and the resulting acantholysis which closely reflects the human . . .

     

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