Mechanisms of direct and indirect presentation of self-antigens in the thymus

HIGHLIGHTS

  • who: Jiri Brezina from the Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia Sapienza University of Rome, Italy have published the article: Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus, in the Journal: (JOURNAL)
  • what: In this review, the authors will highlight the current knowledge concerning the pathways by which self-antigens are presented in the thymus and how they lead to establishment of both recessive and dominant tolerance. This experiment showed that in the absence of AIRE, TCR sequences which were usually found . . .

     

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