Mechanisms of length-dependent recognition of viral double-stranded rna by rig-i

HIGHLIGHTS

• who: Jung Hyun Im from the DivisionKyoto University Chiba, u20118673, Japan have published the article: Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I, in the Journal: Scientific Reports Scientific Reports
• what: The authors propose a new model describing how RIG-I recognizes short dsRNA efficiently and is refractory to long dsRNA for triggering antiviral signaling to MAVS.
• how: The results showed that RIG-I bound to LMW poly (IC) dissociated rapidly whereas RIG-I/HMW poly (IC) complex was stable. The authors examined if dissociated RIG-I retained . . .
  

   

  

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