HIGHLIGHTS
- who: Rachel Occhiogrosso Abelman and collaborators from the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA have published the paper: Mechanisms of Resistance to Antibody-Drug Conjugates, in the Journal: Cancers 2023, 15, 1278. of /2023/
- what: Altogether, categorizing resistance mechanisms with this approach provides direction for future research to further understand these mechanisms and new targets for drug development that can expand the efficacy of antibody-drug conjugates.
SUMMARY
Efforts to characterize and define the mechanisms to explain resistance have incorporated both pre-clinical models and clinical investigation, spanning . . .
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