Mechanisms underlying cognitive deficits in a mouse model for costello syndrome are distinct from other rasopathy mouse models

HIGHLIGHTS

• who: Jadwiga Schreiber from the Department of Neuroscience, Erasmus Medical Centre Rotterdam, CN Rotterdam, The Netherlands have published the research: Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models, in the Journal: Scientific Reports Scientific Reports of 24/03/2017
• what: The authors report that a mouse model for Costello syndrome (CS), which carries an activating mutation in the HRAS gene, shows hyperactivation of the RAS-ERK pathway, learning deficits, structural brain abnormalities, and alterations in synaptic functioning. To detect or rule out meaningful, statistically significant . . .
  

   

  

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