Mechanisms underlying the control of progesterone receptor transcriptional activity by sumoylation*

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• who: Hany Abdel-Hafiz from the Hany Abdel-Hafiz1, Michelle LDudevoir, and Kathryn B. Horwitz From the Department of Medicine, Division of Endocrinology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado , Posttranslational modification by small ubiquitin-like modifier (SUMO) is a major regulator of transcription. We previously showed that progesterone receptors (PR) have a single consensus u243aKXE SUMO-conjugation motif centered at Lys, in the, terminal domain of PR-B and a homologous site of PR-A. SUMOylation of the PR is hormone-dependent and has a suppressive effect on transcription of an exogenous promoter. Here . . .
  

   

  

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