Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

HIGHLIGHTS

• who: Vicente J. Planelles-Herrero from the Research University, South San Francisco, CA, USA have published the Article: Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The mechanism revealed here for OM based on the visualization of its binding_site is in agreement with the current model the authors have proposed in which Pi is released from a state with the lever arm still primed10, 11.

SUMMARY

The PR state is not the step in the myosin cycle . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or E-mail:

If you don't have an account, you can create one here.