Mechanistic characterization of toxoplasma gondiithymidylate synthase (ts-dhfr)-dihydrofolate reductase

HIGHLIGHTS

• who: Eric F. Johnson from the (UNIVERSITY) have published the paper: Mechanistic Characterization of Toxoplasma gondiiThymidylate Synthase (TS-DHFR)-Dihydrofolate Reductase, in the Journal: (JOURNAL) of August/15,/2002
• what: To elucidating the detailed kinetic scheme for this enzyme, this work provides the first direct kinetic evidence for the formation of a TS intermediate and for half-sites TS reactivity in human and Escherichia coli monofunctional TS and in T. gondii and Leishmania major bifunctional TS-DHFR. The focus of this simulation was to validate the minimal kinetic mechanism elucidated in this study. Although this . . .
  

   

  

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