Mechanistic insights on the inhibition of c5 dna methyltransferases by zebularine

HIGHLIGHTS

• who: Christine Champion and colleagues from the University Bremen, School of Engineering and Science, Bremen, Germany have published the article: Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine, in the Journal: (JOURNAL) of August/24,/2010
• what: The authors show by denaturing gel analysis that the intermediate covalent complex between the enzyme and the DNA is reversible differing thus from 5-fluorodeoxycytidine. Fourth the authors show that the ternary complex with AdoMet, DNMT and DNA containing zebularine is much more stable than the one formed with unmodified DNA. In a first part . . .
  

   

  

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