Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo mat2a inhibition

HIGHLIGHTS

• What: The authors show here that, in addition to altering PC levels, MATi affected several proteins involved in both lipid metabolism and the progression of NAFLD .
• Who: Valentina Fogal from the (UNIVERSITY) have published the Article: Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition, in the Journal: (JOURNAL)
• How: Data was analyzed using Spectronaut V15.7.2 (Biognosys AG) direct DIA analysis using an isoform Rat database (UniProt downloaded 22.02.2021) consisting of 9746 protein entries utilizing the Pulsar search engine. The authors designed . . .
  

   

  

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