Mek inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive gnaq

HIGHLIGHTS

• who: Sandra Schrenk from the (UNIVERSITY) have published the Article: MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ, in the Journal: (JOURNAL) of 17/Nov/2021
• what: The authors report a mouse model expressing hyperactive mutant GNAQ in endothelial cells. Mechanistically, by transcriptomic analysis the authors demonstrate increased mitogen activated protein kinase signaling in the mutant endothelial cells. The authors show that the GNAQ mutation p.Q209L is sufficient for the formation of hyperproliferative vascular lesions when driven solely in EC. The authors further demonstrate the essential role . . .
  

   

  

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