Mek1 drives oncogenic signaling and interacts with parp1 for genomic and metabolic homeostasis in malignant pleural mesothelioma

HIGHLIGHTS

• who: Haitang Yang from the DepartmentTong University Bern, Bern, Switzerland have published the paper: MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma, in the Journal: (JOURNAL) of 23/08/2022
• what: The authors show that inhibition of the pathway by MEKi elicits a protective mechanism involving the pleiotropic PARP1, and that the combination of PARPi and MEKi enhances MPM cell death in_vitro and in_vivo. Mechanistically, the authors show that concurrent PARPi treatment amplifies MEKi-induced HR deficiency and metabolic dysfunction, and that MEKi/PARPi cytotoxicity is . . .
  

   

  

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