HIGHLIGHTS
- who: Juan Feng from the (CSIC), Spain have published the paper: Melatonin prevents cyclophosphamide-induced primordial follicle loss by inhibiting ovarian granulosa cell apoptosis and maintaining AMH expression, in the Journal: (JOURNAL)
- what: The authors demonstrated that Cyc treatment promoted apoptosis of ovarian granulosa cells through the mitochondrial apoptotic pathway.
- how: The results showed that Cyc significantly increased the expression of cleavedcaspase3 Bax and cytoplasmic Cyt-c and decreased the expression of Bcl-2 in ovaries (P and amplt 0.05).
SUMMARY
AMH is an important negative regulator of . . .
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