Menin maintains cholesterol content in colorectal cancer via repression of lxr-mediated transcription

HIGHLIGHTS

• who: Thomas E. Nyul et al. from the Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA have published the Article: Menin Maintains Cholesterol Content in Colorectal Cancer via Repression of LXR-Mediated Transcription, in the Journal: (JOURNAL)
• what: The authors aimed to uncover novel menin-regulated pathways important for colorectal carcinogenesis. The authors demonstrate that menin serves as a repressor of the transcription of LXR-target genes in both CRC cell lines and benign colonic epithelium in_vitro and in_vivo. The authors show that the inhibition of menin reduces . . .
  

   

  

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