HIGHLIGHTS
- who: Patrick C. Lee et al. from the Department, Boston, Massachusetts, USAUniversity of have published the research: Merkel cell carcinoma, in the Journal: (JOURNAL) of May/27,/2021
- what: PRC2 was recently identified as an HLA-I repressor through independent CRISPR screens in leukemia and lym12 phoma cell lines , and this work shows a connection to PRC1.1 as well.
- how: To account for potential immune cell infiltration which might confound mea- surement of bulk class I expression the authors applied ESTIMATE to calculate tumor purity (median 87% purity range 41%-99%). One . . .
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