Mers-cov orf4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice

HIGHLIGHTS

• who: Melissa Bello-Perez et al. from the Universidad Autou0301noma de Madrid, Darwin, Madrid, Spain, Veterinary Pathology Department, Animal Health have published the paper: MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice, in the Journal: (JOURNAL)
• what: This study provides indirect evidence of increased autophagy in the absence of 4b protein in MRC-5 infected cells, as shown by the decrease in the levels of p62 substrate and the increase in ULK1 protein when 4b protein was deleted from the viral genome.
• how . . .
  

   

  

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