Metabolic and microbiome alterations following the enrichment of a high-fat diet with high oleic acid peanuts versus the traditional peanuts cultivar in mice

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SUMMARY

Experimental groups were as follows: normal-diet (ND), HFD, HFD with "Hanoch" peanuts (HFDh), w/w 4%, HFD with high oleic acid "Hanoch-Oleic" peanuts (HFDo), w/w 4%. Pro-inflammatory cytokines, other adipokines, along free fatty_acids (FFA) secreted from adipose_tissue may trigger and/or aggravate the development of IR and other pathological repercussions. Specifically, their role on the liver, adipose_tissue, and gut microbiota was evaluated. Liver and adipose_tissues were removed, weighed, placed in liquid nitrogen, and stored at -80◦ C. A small liver sample was also embedded in 4% formaldehyde. Quantitative changes in . . .

 



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