HIGHLIGHTS
- who: Zheng-Shan Chong from the (UNIVERSITY) have published the research: Metabolic contributions to neuronal deficits caused by genomic disruption of schizophrenia risk gene SETD1A, in the Journal: (JOURNAL) of 28/07/2022
- what: The authors generated a human iPSC model of SETD1A haploinsufficiency that recapitulates several neuronal phenotypes reported in previous studies on SETD1A+/- mice, namely impaired neurite outgrowth and reduced spontaneous activity18,19. The authors demonstrate that SETD1A loss-of-function also leads to metabolic dysregulation and that providing SETD1A+/- neurons with alternative metabolic substrates like pyruvate and lactate is sufficient to rescue . . .
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