Metabolic flux analysis of 3d spheroids reveals significant differences in glucose metabolism from matched 2d cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines

HIGHLIGHTS

• who: Tia R. Tidwell from the Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway have published the research: Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines, in the Journal: (JOURNAL)
• what: In this study of CRC and PDAC cell lines the authors demonstrate that glucose in 3D spheroids differs significantly from 2D cultures both in terms of glycolytic and oxidative phosphorylation metrics. The authors show how growth rates, live metabolic flux measurements, substrate utilization . . .
  

   

  

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