Metal-free synthesis of 3-tri uoromethyl-1,2,4-triazoles via multi-component reaction of uoroacetimidoyl chlorides, hydrazine hydrate and benzene-1,3,5-triyl triformate

HIGHLIGHTS

• who: -triazole and collaborators from the Stony Brook University, United States have published the research work: Metal-free synthesis of 3-tri uoromethyl-1,2,4-triazoles via multi-component reaction of uoroacetimidoyl chlorides, hydrazine hydrate and benzene-1,3,5-triyl triformate, in the Journal: (JOURNAL)
• how: Other acidic additives were also examined including TfOH PivOH and TFA and the results indicated that TFA promoted the reaction with highest efficiency .

SUMMARY

1,2,4-Triazoles, especially trifluoromethyl-substituted 1,2,4-triazoles, have found extensive applications in the field of . . .

 



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