HIGHLIGHTS
SUMMARY
Recommended current diagnostic approaches for patients with metastatic melanoma include ultrasound, magnetic_resonance imaging (MRI), and positron emission tomography (PET)-CT which play important roles in tumor staging, surveillance, and assessment of therapeutic response. Alegre and collaborators underlined the possible prognostic role of exosomes with a study that examined the presence of biomarkers such as melanoma inhibitory activity (MIA), S100B, and tyrosinase-related protein 2 (TYRP2) in exosomes obtained from the serum of healthy donors, metastatic melanoma, and melanoma disease-free patients. Most recently, Sabato et_al characterized plasma EVs associated with miRNAs (pEV-miRNAs) profiles . . .
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