HIGHLIGHTS
- who: David E. Lee from the Animals All animal experiments and care followed the guidelines and were approved by the Institutional Animal Care and Use Committee at Duke University Medical CenterFor all experiments, /BL J mice were acquired through the National Institute of Aging animal colony and used for experiments at, months of age (labeled as u2018Young`) or at age, months (u2018Old`). For parabiosis and bone marrow transplant experiments, Metrnl knockout mice (Metrnl-/-) were previously described5. All mice were house in climate-controlled facility with temperature maintained at , u00b0C u00b1 , u00b0C, humidity maintained between, %, and light/dark . . .
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