Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic in ammation and microglial activation in female mice

HIGHLIGHTS

  • who: October and colleagues from the University of Barcelona, Spain have published the research: Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic in ammation and microglial activation in female mice, in the Journal: (JOURNAL)
  • what: The authors aimed to determine whether hypothalamic inflammation is induced independently by OLZ and whether the protective effect of MET is mediated by the regulation of hypothalamic inflammation and microgliosis. In the experiment , the authors compared hypothalamic microglial changes between male and female mice.
  • how: The data showed that leptin-induced anorexigenic effect was decreased . . .

     

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